| | Defensive Stats for Week #1 |
| | Player | | Team | | # | | INTs | | Sacks | | TDs | | Rating |
| | Raiders | 88 | 0 | 4 | 0 | 4 |
| | Rams Team | Rams | 9999 | 0 | 3 | 0 | 3 |
| | Al Noviello | Rams | 11 | 0 | 3 | 0 | 3 |
| | Frank Jacinto | Patriots | 7 | 0 | 3 | 0 | 3 |
| | Luis DeLeon | Vikings | 0 | 1 | 0 | 0 | 2 |
| | Todd Giaquinto | Rams | 88 | 1 | 0 | 0 | 2 |
| | Paul Silva | Patriots | 19 | 1 | 0 | 0 | 2 |
| | Michael Newsome | Bengals | 5 | 1 | 0 | 0 | 2 |
| | Raiders Team | Raiders | 9999 | 0 | 1 | 0 | 1 |
| | Patriots Team | Patriots | 9999 | 0 | 1 | 0 | 1 |
| | Dolphins Team | Dolphins | 9999 | 0 | 1 | 0 | 1 |
| | Frank Ribezzo | Dolphins | 80 | 0 | 1 | 0 | 1 |
| | Bengals Team | Bengals | 9999 | 0 | 1 | 0 | 1 |